Amplification of mRNAs from Single, Fixed, TUNEL-Positive Cells

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Amplification of mRNAs from single, fixed, TUNEL-positive cells.

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Increased TUNEL positive cells in human alcoholic brains.

Alcohol-sensitive neuronal cell loss, which has been reported in the superior frontal cortex and hippocampus, may underlie the pathogenesis of subsequent cognitive deficits. In the present study, we have used the TUNEL labeling to detect the DNA damage in human alcoholic brains. Seven out of eleven alcoholics exhibited TUNEL-positive cells in both superior frontal cortex and hippocampus, which ...

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ژورنال

عنوان ژورنال: BioTechniques

سال: 1998

ISSN: 0736-6205,1940-9818

DOI: 10.2144/98254bm04